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Treaty of Cambrai
France's Francois I renounced the Treaty of Madrid, once he was released from captivity, claiming he had been coerced into signing it. He then declared war on Charles V and once again invading Italy after he had entered into an alliance with William of England. Francois managed to lay seige to Naples, but due to a typhus epidemic that was ravaging Italy, 19,000 out of 25,000 of Francois army was lost to the disease. The French are forced to withdraw. In August 1529 Francois agreed once agains to a treaty where he renounced all claims to Italy and agreed to pay a ransom of 2,000,000 crowns. The ongoing wars for Italy effectively ended the Italian Renaissance.